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The MICROSCOPE Project

Early Career Surgeons Mental Wellbeing Patients Outcomes Mentorship +2

This multicenter observational prospective study aims to explore the impact of peri-operative support measures (mentorship or coaching or intraoperative consultation) on the mental well-being of early career surgeons. Furthermore sub-analyses will be conducted to explore the impact that surgeons mental wellbeing related to different support measures could have on patients' outcomes

Начало: 01.06.2026 Край: 31.12.2027 Възраст: от 18 г.

Italy Niguarda Hospital NCT07153224

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MOCHA: Embedded Inpatient Mental Health Care for High-Risk Perinatal Patients

Anxiety Disorders Stress Disorders, Post-Traumatic Pregnancy, High Risk Depressive Disorder, Major +2

Pregnant and postpartum patients hospitalized for medical complications experience high rates of depression, anxiety, and trauma-related symptoms, yet access to timely psychiatric care during obstetric hospitalization is limited. Project MOCHA integrates early mental health screening, trauma-informed psychotherapy, and structured follow-up into routine inpatient maternity care for individuals at elevated clinical risk. This single-arm implementation study examines the feasibility, acceptability, and fidelity of delivering a Collaborative Mental Health Care Program within a high-risk obstetric inpatient setting. The program includes brief inpatient psychotherapy, symptom monitoring, and post-discharge follow-up over three months. Preliminary changes in depression, anxiety, attention-deficit hyperactivity disorder, and posttraumatic stress symptoms will be assessed to inform future effectiveness trials and broader health system integration.

Начало: 01.06.2026 Край: 01.06.2027 Възраст: 18–100 г.

United States Indiana University NCT07540585

Предстои набиране Фаза 4

Workflow Optimization During Pulse Field Ablation for Atrial Fibrillation

Pulsed Field Ablation Lidocaine

To evaluate the efficacy and safety of intravenous lidocaine in reducing diaphragmatic contraction and suppressing the cough reflex during pulsed field ablation procedures.

Начало: 01.06.2026 Край: 31.12.2030 Възраст: от 18 г.

Taiwan National Taiwan University Hospital NCT07354217

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Factors Affecting Immediate Anterior Implants Esthetics.

Pink Esthetic Score Implant Survival Rate Immediate Implant Placement

This retrospective cohort study evaluates clinical, surgical, and prosthetic factors associated with early and mid-term outcomes of immediate implant placement in the anterior maxilla. The primary objective is to identify predictors of implant survival and complications (e.g., infection, soft-tissue dehiscence, esthetic failure) within 12 months following placement. Secondary objectives include assessment of peri-implant marginal bone loss, prosthetic complications, and esthetic outcomes (pink esthetic score).

Начало: 01.06.2026 Край: 01.09.2026 Възраст: 21–55 г.

International Dental Contiuing Education NCT07539168

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A System to Help With Freezing of Gait in Parkinson's Patients

Freezing of Gait Symptoms in Parkinson Disease

The goal of this clinical trial is to learn if the ParkinSense system, a customizable, multimodal, and adaptable cueing system, can assist with freezing of gait (FOG) in patients with Parkinson's disease. The main question it aims to answer is: is the percent of time spent frozen reduced when using the system compared to not using the system? Participants will be asked to take part in a single-visit laboratory study where they will wear the system in a controlled environment, followed by a two weeks of home use.

Начало: 01.06.2026 Край: 31.05.2027 Възраст: от 21 г.

United States Barron Associates, Inc. NCT07542743

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The Comparative Effectiveness Evaluation of the Impact of Digital Education

Pediatric Cancer

This study is being conducted to determine how best to educate caregivers about cancer and its treatment. When caregivers are well-informed, they are more confident in supporting their child through treatment, which can improve treatment adherence.

Начало: 01.06.2026 Край: 31.08.2028 Възраст: от 18 г.

Duke University NCT06979310

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VIRal Pulmonary Infections in Older AGE

Viral Pulmonary Infections

Severe acute respiratory infections (SARIs) represent one of the leading causes of hospitalization and mortality worldwide. These infections are associated with substantial in-hospital mortality and often constitute a turning point in the medium-term prognosis of older patients and those with comorbid conditions. SARIs are most frequently of viral origin, involving well-known pathogens such as Orthomyxoviridae (influenza A and B viruses), Pneumoviridae \[(respiratory syncytial virus (RSV), human metapneumovirus (hMPV)\], Paramyxoviridae \[parainfluenza viruses (PIV)\], adenoviruses, or rhinoviruses, as well as emerging viruses such as pandemic influenza strains and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic. Age-related immune decline (immunosenescence) increases the risk of severe forms and related respiratory or cardiovascular complications. However, the prevalence and burden of the different viral etiologies of Severe acute respiratory infections (SARIs) in older adults remain limited and insufficiently characterized. The primary objective is to determine the proportion of viral respiratory infections attributable to polymerase chain reaction (PCR)-confirmed pathogen agents among hospitalized older subjects (≥60 years old).

Начало: 01.06.2026 Край: 30.09.2028 Възраст: от 60 г.

France Gérond'if NCT07539103

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Moderate-Intensity Statin Plus Ezetimibe in CKD and ASCVD

Renal Insufficiency Atherosclerosis Dyslipidemia Hypercholesterolemia +1

The ULTRA-CKD trial is a prospective, randomized, open-label, multicenter trial designed to compare the efficacy and safety of moderate-intensity statin plus ezetimibe combination therapy versus high-intensity statin monotherapy in patients with chronic kidney disease (CKD) and concomitant atherosclerotic cardiovascular disease (ASCVD). Patients with CKD are at very high risk for ASCVD. In this population, it is important to establish a lipid-lowering strategy that optimizes cardiovascular outcomes while ensuring long-term safety. While high-intensity statins are generally considered as initial treatment option for secondary prevention, the optimal strategy for CKD patients remains to be clinicaly defined. This study aims to evaluate whether the combination of moderate-intensity statin and ezetimibe is non-inferior to high-intensity statin monotherapy in terms of 3-year composite of major adverse cardiovascular events.

Начало: 01.06.2026 Край: 22.01.2031 Възраст: 19–85 г.

Yonsei University NCT07524101

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Large Language Model-Generated Messages to Improve Guideline-Directed Medical Therapy in Heart Failure

Heart Failure

This study is an investigator-initiated, cluster-randomized implementation trial evaluating a large language model (LLM)-based clinical decision support (CDS) tool designed to improve guideline-directed medical therapy (GDMT) for adult patients with heart failure seen in outpatient cardiology clinics at Mass General Brigham. For eligible heart failure encounters, the CDS tool reviews existing electronic health record (EHR) data, including diagnoses, medications, vital signs, laboratory results, and recent notes, and generates brief, clinician-facing messages suggesting opportunities to initiate or optimize GDMT and highlighting relevant safety considerations. Messages are delivered to cardiology providers via Epic InBasket and/or institutional email prior to scheduled visits. The tool is advisory only and cannot place orders or change medications automatically; all treatment decisions remain at the discretion of the treating clinician and patient. Cardiology providers are assigned at the provider/clinic level to early implementation of the CDS tool versus usual care (no messages) during the initial phase. The primary outcome is GDMT optimization within 30 days of an index visit. Secondary outcomes include feasibility of CDS generation and delivery and a 30-day safety composite (e.g., heart failure hospitalization, acute kidney injury, hyperkalemia, hypotension or bradyarrhythmia plausibly related to GDMT).

Начало: 01.06.2026 Край: 01.12.2027 Възраст: 18–85 г.

United States Brigham and Women's Hospital NCT07337577

Предстои набиране Фаза 4

Trial of an AI-enabled Digital Stethoscope to Improve Antibiotic Stewardship

Respiratory Infections in Children

Antibiotics are a mainstay of the treatment of lower respiratory infections in young children even though most episodes are caused by self-limiting viruses. Innovative child friendly tools that improve the diagnosis of respiratory illnesses, safely reduce the unnecessary use of antibiotics, and are suitable for implementation in resource-constrained settings are urgently required to safely improve antibiotic stewardship and stem the rising rates of antibiotic resistance globally. In the Bangladesh Lung Auscultation Artificial Intelligence for Antibiotic Stewardship Trial (BLAAAST) the investigators aim to determine whether treatment failure frequency among children in rural Bangladesh managed by clinical guidelines enhanced by a commercially available, artificial intelligence (AI)-enabled digital stethoscope is non-inferior to guidelines alone. The investigators hypothesize treatment failure frequency among 'enhanced IMCI' participants will be no worse than standard care by a +/-2% margin, safely reducing antibiotic use by 50-60%. The investigators will also evaluate if a diagnostic strategy enhanced by an AI-enabled digital stethoscope is a sustainable alternative to standard care for children in rural Bangladesh. The investigators hypothesize that care augmented by an AI-enabled digital stethoscope will have additional benefits via reduced antibiotic use that will outweigh digital auscultation costs resulting in cost-effectiveness compared to current practice. BLAAAST affords a unique opportunity to evaluate the efficacy of clinical guidelines enhanced by an AI-enabled digital stethoscope on child pneumonia outcomes in Bangladesh, if digital auscultation may be instrumental in the wider antibiotic stewardship strategy, and whether a digital stethoscope diagnostic tool is cost-effective in the care of children with respiratory illnesses.

Начало: 01.06.2026 Край: 30.06.2029 Възраст: 2–59 г.

Bangladesh Johns Hopkins University NCT07362433

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Subclinical Atherosclerosis in Juvenile Systemic Lupus Erythematosus

Atherosclerosis

The aim of this study is to evaluate subclinical atherosclerosis in children and adolescents with juvenile SLE by measuring carotid intima-media thickness (CIMT), and to determine its associations with traditional cardiovascular risk factors (dyslipidemia, hypertension, obesity) and non-traditional disease-related risk factors (disease activity, lupus nephritis, corticosteroid dose, disease duration).

Начало: 01.06.2026 Край: 01.08.2027 Възраст: до 18 г.

Assiut University NCT07545408

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Relief Efficacy of Lidocaine Versus Morphine for Acute Renal Colic in the Emergency Department

Renal Colic Kidney Stones, Urolithiasis, Hypocitraturia Opioid Use During Medical Care

The opioid epidemic continues to be a major public health crisis in the United States. According to the Center for Disease Control, approximately 8 million Americans reported misusing prescription opioids in 2023, with over 5 million Americans reporting that they suffer from opioid use disorder. The United States government estimates that 105,000 people died from drug overdose in 2023, and approximately 80,000 of those deaths can be attributed to opioids (\~76%). In acknowledgement of the opioid crisis, we wish to contribute to ongoing efforts to reduce unnecessary and excessive opioid prescription. In 2012, researchers in Iran published a randomized controlled trial comparing intravenous (IV) lidocaine to IV morphine for acute renal colic, reporting that 90% patients responded "successfully" in the lidocaine group versus 70% in the morphine group. They also concluded that there was a statistically significant difference between pain scores between the two groups at all time points, favoring the lidocaine group. However, the study was conducted at a single emergency department in Tabriz, Iran, with a relatively homogenous patient population, and the researchers did not explicitly define their primary outcome variable for what constituted a "successful" response in the treatment groups. The investigators of this study aim to build upon this preliminary evidence by recruiting a more diverse population to improve generalizability and by predefining pain-reduction thresholds to allow for more meaningful comparison between the interventions.

Начало: 01.06.2026 Край: 01.06.2028 Възраст: от 18 г.

Loma Linda University NCT07536594

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Signature Development and Validation Protocol for an Epigenetic Assay in Diagnosing Breast Cancer

Breast Cancer (Locally Advanced or Metastatic) Healthy Volunteers (HV) Unhealthy Volunteers Breast Cancer Screening

The purpose of this research study is to test a new process for diagnosing breast cancer by examining changes to your DNA that can be detected from a blood test. The information we learn by doing this study could potentially help people in the future. Participants in this study will have blood samples collected, have their medical records reviewed by study personnel and fill out questionnaires at different time points during the study. Blood sample collection will occur during normal routine clinic visits. Participation in this study will last approximately 5 years.

Начало: 01.06.2026 Край: 01.07.2032 Възраст: от 18 г.

United States University of Maryland, Baltimore NCT07374796

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Effect of Osteopathic Intervention on Migraine

Migraine

Migraine is a common, disabling neurological condition characterized by severe, often unilateral pain accompanied by sensory symptoms like nausea and photophobia. Its pathophysiology involves activation of the trigeminovascular system, neuro-inflammation, and nervous system sensitisation. Due to the convergence of trigeminal and cervical nerves in the upper neck (C2), manual therapy may influence migraine symptoms. Osteopathic techniques, such as suboccipital inhibition and C2 manipulation, aim to reduce pain intensity and frequency by normalising mobility and reducing nociceptive stimulation. While promising, further research is needed to validate these interventions through rigorous clinical trials.

Начало: 01.06.2026 Край: 01.09.2026 Възраст: 18–50 г.

Escola Superior de Tecnologia da Saúde do Porto NCT07542340

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Symptoms of Anxiety and/or Depression and SDM in Older Patients With CLTI

Critical Limb Threatening Ischaemia Depression Disorder Anxiety

Mental health disorders are common in older people and are often unrecognised. Those living with mental health disorders who are being considered for vascular surgery have worse post operative outcomes, including longer length of hospital stay, higher readmission rates and emergency admissions to hospital. These patients also have more medical conditions contributing to their post surgery complications and poor health outcomes. Surgery for vascular patients can include life changing operations, such as amputation, which impacts mental health and quality of life. Shared decision making is the process whereby patients and clinicians work together to make evidence based decisions centred on patient values and preferences and is part of the Comprehensive Geriatric Assessment and optimisation (CGA) model of care. SDM has been shown to improve patient experience through provision of realistic choice, enhanced interaction with clinicians, greater empowerment and increased confidence and trust in healthcare provision. Implementing SDM in vascular patients can be particularly challenging. Evaluating and communicating benefits and risks of available treatments for CLTI in a complex older patient population requires additional consideration beyond the inherent surgical risks. To achieve truly informed SDM, the clinician requires knowledge of the impact of co-existing conditions on postoperative recovery, the natural history of the surgical pathology with and without surgery and an awareness of the benefits and risks of alternative treatments underpinned by skilful communication.

Начало: 01.06.2026 Край: 01.12.2026 Възраст: от 65 г.

United Kingdom Guy's and St Thomas' NHS Foundation Trust NCT07529886

Предстои набиране Фаза 1/2

A Study of Inotuzumab and Blinatumomab in People With B-cell Acute Lymphoblastic Leukemia

B-cell Acute Lymphoblastic Leukemia B-Cell Acute Lymphoblastic Leukemia, Adult B-ALL

The purpose of this study is to find out whether combining inotuzumab and blinatumomab is a safe and effective treatment for participants with newly diagnosed B-cell acute lymphoblastic leukemia (B-ALL).

Начало: 01.06.2026 Край: 01.01.2029 Възраст: 18–55 г.

United States Memorial Sloan Kettering Cancer Center NCT07313852

Предстои набиране Фаза 2

Testing the SurVaxM Vaccine for Lung Cancer Prevention

Lung Carcinoma

This phase II trial tests how well a survivin peptide vaccine called SurVaxM works in preventing lung cancer in high risk patients. Upon administration, the SurVaxM vaccine activates the immune system to produce an immune cell response against cancer cells that express a protein called survivin. This may result in decreased tumor cell proliferation and lead to tumor cell death. SurVaxM is given with montanide, a substance that helps the immune system respond to the SurVaxM vaccine, followed by sargramostim, which is given to increase the number of white blood cells in the body. The SurVaxM vaccine may help the body make special proteins called antibodies, which may be helpful in preventing the development of lung cancer.

Начало: 01.06.2026 Край: 30.09.2029 Възраст: от 18 г.

United States National Cancer Institute (NCI) NCT07169617

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Occlusal Changes After Modified Hall Technique in Molars Affected by Molar-Incisor Hypomineralization

Dental Caries Dental Occlusion Pediatric Dentistry

Molar-incisor hypomineralization (MIH) frequently affects permanent first molars and increases the risk of rapid post-eruptive breakdown and restorative failure. Stainless steel crowns (SSCs) are considered a reliable treatment option for severely affected molars; however, SSC placement may temporarily alter the occlusal vertical dimension and occlusal contacts. Quantitative evidence describing the occlusal adaptation process following SSC placement in MIH-affected permanent molars is limited. This prospective longitudinal clinical study aims to evaluate occlusal adaptation after SSC placement using the modified Hall technique in MIH-affected permanent first molars. Forty-six children will be included. Intraoral scans will be obtained at baseline, immediately after treatment, and during follow-up visits up to 3 months. Digital models will be superimposed to measure three-dimensional changes in cusp position, occluso-vertical dimension, and occlusal contact area. Temporomandibular joint function and periodontal parameters will also be assessed. The results are expected to provide quantitative evidence on occlusal adaptation following SSC treatment in MIH-affected molars.

Начало: 01.06.2026 Край: 01.12.2027 Възраст: 6–14 г.

Turkey (Türkiye) Ankara Yildirim Beyazıt University NCT07530835

Предстои набиране Фаза 2

T4/T3 Therapy in Hypothyroidism

Hypothyroidism Primary

This study will test whether 6 months of combination therapy with levothyroxine (LT4) plus liothyronine (LT3) is superior to LT4 plus placebo in participants with hypothyroidism who have residual symptoms of hypothyroidism with TSH levels within the reference range.

Начало: 01.06.2026 Край: 01.06.2027 Възраст: 18–70 г.

United States University of Pennsylvania NCT07424183

Предстои набиране Фаза 2

ASTRAEA: ReinvigorAting ReSponse To ImmunotheRApy in MEtAstatic TNBC With Combination Myeloid Inhibition and Radiation

TNBC - Triple-Negative Breast Cancer Breast Cancer

Open label, single-arm, prospective therapeutic trial. Pembrolizumab (MK-3475), 200 mg IV Q3W starting at C1D1/Week 1 for up to 2 years, until disease progression, or treatment intolerance. RT, 8 Gy x 3 fractions over 3 consecutive days at C1D8/Week 2; Axatilimab (SNDX-6352; INCA034176), 1 mg/kg, IV, Q2W starting 1 week post- RT C1D15/Week 3 until disease progression or treatment intolerance.

Начало: 01.06.2026 Край: 01.07.2033 Възраст: от 18 г.

United States Stephen Shiao NCT07015853

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